Alzheimer's disease and neurodegeneration: visualising the invisible

July 16, 15:30 - 16:30 CEST

NH 13-1
Introduction by the moderator
Sven Haller, Geneva / CH
NH 13-2
Visualising the human glymphatic system
Lydiana Hirschler, Leiden / NL
Learning Objectives
1. To become familiar with the glymphatic system.
2. To appreciate the role of the glymphatic system in the clearance of amyloid-β and tau.
3. To highlight experiences with MRI of the glymphatic system in normal pressure hydrocephalus dementia.
4. To understand how reduced glymphatic and lymphatic clearance function may be associated with neurodegenerative disease.
NH 13-3
PET as part of the biomarker toolbox for early clinical diagnosis of Alzheimer's disease
Javier Arbizu, Pamplona / ES
Learning Objectives
1. To learn about the different radiotracers available to evaluate the specific processes involved in the neurodegenerative conditions found in dementia
. 2. To understand the benefit of PET molecular imaging in the diagnostic workup of Alzheimer's disease.
3. To appreciate the role of different PET and SPECT techniques in the differential diagnosis of neurodegenerative disorders.4. To become familiar with the methodology to perform and read PET molecular imaging in dementia.
NH 13-4
Imaging beyond beta-amyloid and tau: insights from high-field MRI
Louise van der Weerd, Leiden / NL
Learning Objectives
1. To appreciate the technical advantages and disadvantages in the use of ultra-high field MRI.
2. To learn about the mechanisms of MRI contrasts at ultra-high field.
3. To learn about underlying pathophysiological sources of MRI contrast and the disease specificity of different MRI biomarkers.
4. To list promising applications of ultra-high field MRI in Alzheimer's disease and other neurodegenerative diseases.
NH 13-5
Integrating population imaging with clinical imaging for the memory clinic
Meike Vernooij, Rotterdam / NL
Learning Objectives
1. To overview current practice for memory clinic imaging in Europe and appreciate the limitations for research.
2. To describe major initiatives in population imaging and understand some of the technical and logistical challenges these studies face.
3. To describe the opportunities and challenges associated with integrating information from large population datasets such as The Rotterdam Study or UK Biobank with individual imaging for the memory clinic.
NH 13-6
Live Q&A: Over 100 years of hype and hope in dementia and Alzheimer's research: what lessons have we learned, and what are the future directions?



Sven Haller

Geneva, Switzerland