EIBALL Workshop

EIBALL WS - Building a quantitative imaging research study

February 28, 16:00 - 17:30 CET

10 min

Introduction: the EIBALL and QIBA initiative

20 min

Hypothesis generation: including primary/secondary endpoints and ground truth, inclusion, exclusion criteria

To learn about the introduction of quantitative imaging endpoints in clinical research studies.
To appreciate the relationship between measured biomarkers, ground truth and clinical endpoints.
To understand the principle of reliable quantitative imaging biomarkers (QIBs) and its relation to clinical endpoints.

20 min

Making the measurement: including precision, reproducibility, validation

To learn about the use of metrology concepts in quantitative imaging.
To appreciate terms like precision, accuracy, bias, reliability and reproducibility in quantitative imaging measurements.
To understand the necessity of standardised imaging procedures for the measurements of QIBs.

20 min

Statistical considerations: including study type, main tests, outcome measurements, biases

To learn about appropriate statistical concepts for the use of QIBs in clinical research studies.
To appreciate accuracy and bias of QIBs and its statistical representation.
To understand the selection of useful statistical hypotheses and tests for one or multiple biomarkers based clinical study outcome assessment.

20 min

Practical issues: including ethics and legal, funding, and planning

To learn how to plan, manage and analyse QIB based clinical research studies.
To appreciate organisational setup and requirements to provide reliable and reproducible results.
To understand the challenges of quantitative imaging biomarker studies and how to successfully use them.