EIBALL Workshop
EIBALL WS - Building a quantitative imaging research study
Lectures
1
Introduction: the EIBALL and QIBA initiative
10:00Gudrun Zahlmann, Neumarkt / DE
2
Hypothesis generation: including primary/secondary endpoints and ground truth, inclusion, exclusion criteria
20:00Laure S. Fournier, Paris / FR
3
Making the measurement: including precision, reproducibility, validation
20:00Gudrun Zahlmann, Neumarkt / DE
4
Statistical considerations: including study type, main tests, outcome measurements, biases
20:00Daniel Bos, Rotterdam / NL
5
Practical issues: including ethics and legal, funding, and planning
20:00Michael Vinzenz Knopp, Cincinnati / US
10 min
Introduction: the EIBALL and QIBA initiative
Gudrun Zahlmann, Neumarkt / Germany
20 min
Hypothesis generation: including primary/secondary endpoints and ground truth, inclusion, exclusion criteria
Laure S. Fournier, Paris / France
- To learn about the introduction of quantitative imaging endpoints in clinical research studies.
- To appreciate the relationship between measured biomarkers, ground truth and clinical endpoints.
- To understand the principle of reliable quantitative imaging biomarkers (QIBs) and its relation to clinical endpoints.
20 min
Making the measurement: including precision, reproducibility, validation
Gudrun Zahlmann, Neumarkt / Germany
- To learn about the use of metrology concepts in quantitative imaging.
- To appreciate terms like precision, accuracy, bias, reliability and reproducibility in quantitative imaging measurements.
- To understand the necessity of standardised imaging procedures for the measurements of QIBs.
20 min
Statistical considerations: including study type, main tests, outcome measurements, biases
Daniel Bos, Rotterdam / Netherlands
- To learn about appropriate statistical concepts for the use of QIBs in clinical research studies.
- To appreciate accuracy and bias of QIBs and its statistical representation.
- To understand the selection of useful statistical hypotheses and tests for one or multiple biomarkers based clinical study outcome assessment.
20 min
Practical issues: including ethics and legal, funding, and planning
Michael Vinzenz Knopp, Cincinnati / United States
- To learn how to plan, manage and analyse QIB based clinical research studies.
- To appreciate organisational setup and requirements to provide reliable and reproducible results.
- To understand the challenges of quantitative imaging biomarker studies and how to successfully use them.