MRI findings of shoulder injury related to vaccine administration (SIRVA) following COVID-19 vaccination: A cross-sectional study
Author Block: N. M. I. Obeidat1, R. Khasawneh1, S. Bani Essa1, M. Alkhatatba1, A. Abdel Kareem1, M. Al-Na'Asan1, Y. Alshgerat1, M. Aljarrah1, L. Sawalha2; 1Irbid/JO, 2Amman/JO
Purpose: To investigate the MRI findings of patients presenting with SIRVA after COVID-19 vaccination and to assess the associations between these findings and patient demographics, clinical symptoms, and vaccine-related factors.
Methods or Background: A retrospective cross-sectional study involved patients who reported shoulder disorders following COVID-19 vaccination between 1 May 2021 and 1 May 2022. Data collected included demographics, clinical symptoms, vaccination details, and MRI findings. Statistical analyses assessed associations between MRI findings and patient demographics, clinical symptoms, and vaccine-related factors. Chi-square tests and t-tests were utilized, with statistical significance set at p < 0.05 and trends noted at p < 0.1.
Results or Findings: 35 patients were diagnosed with SIRVA (3 had bilateral involvement; mean age 53.6 ± 9.0 years; 54.3% females). The majority developed symptoms within 24 hours post-vaccination (88%), most of them resolved within a week (84%). Pain was the predominant symptom (51.4%). MRI findings were subacromial bursitis (89.5%), enthesial erosions (63.2%), tendinopathy (47.4%), rotator cuff tears and changes of adhesive capsulitis (each 36.8%), effusion (23.7%), as well as muscle and bone marrow edema (10.5% and 7.9%, respectively). Statistically significant associations were found between tendinopathy and both, older age (p=0.024) and AstraZeneca vaccine (p=0.033), subacromial bursitis with both female gender (p=0.013) and higher BMI (p=0.023), and between changes of adhesive capsulitis and Sinopharm vaccine (p=0.029). Non-diabetics, females, and patients with tendinopathy, were more likely to have persistent symptoms after 3 years following vaccination.
Conclusion: SIRVA following COVID-19 vaccination results in different shoulder pathologies apparent on MRI, many of which are strongly related to patient demographics and type of vaccine administered. Awareness of SIRVA changes among radiologists is paramount, especially in seasons of vaccination campaigns such as in early winter (flu-vaccines).
Limitations: Retrospective study and small patient sample.
Funding for this study: No funding was received for this study.
Has your study been approved by an ethics committee? Not applicable
Ethics committee - additional information: Retrospective study.