EIBALL Workshop

EIBALL WS - Building a quantitative imaging research study

February 28, 16:00 - 17:30 CET

10 min
Introduction: the EIBALL and QIBA initiative
Gudrun Zahlmann, Oak Brook / United States
20 min
Hypothesis generation: including primary/secondary endpoints and ground truth, inclusion, exclusion criteria
Laure S. Fournier, Paris / France
  1. To learn about the introduction of quantitative imaging endpoints in clinical research studies.
  2. To appreciate the relationship between measured biomarkers, ground truth and clinical endpoints.
  3. To understand the principle of reliable quantitative imaging biomarkers (QIBs) and its relation to clinical endpoints.
20 min
Making the measurement: including precision, reproducibility, validation
Gudrun Zahlmann, Oak Brook / United States
  1. To learn about the use of metrology concepts in quantitative imaging.
  2. To appreciate terms like precision, accuracy, bias, reliability and reproducibility in quantitative imaging measurements.
  3. To understand the necessity of standardised imaging procedures for the measurements of QIBs.
20 min
Statistical considerations: including study type, main tests, outcome measurements, biases
Daniel Bos, Rotterdam / Netherlands
  1. To learn about appropriate statistical concepts for the use of QIBs in clinical research studies.
  2. To appreciate accuracy and bias of QIBs and its statistical representation.
  3. To understand the selection of useful statistical hypotheses and tests for one or multiple biomarkers based clinical study outcome assessment.
20 min
Practical issues: including ethics and legal, funding, and planning
Michael Vinzenz Knopp, Cincinnati / United States
  1. To learn how to plan, manage and analyse QIB based clinical research studies.
  2. To appreciate organisational setup and requirements to provide reliable and reproducible results.
  3. To understand the challenges of quantitative imaging biomarker studies and how to successfully use them.

Participants are required to sign up in advance. More information on the sign-up system will be available soon.

This session will not be streamed, nor will it be available on-demand!